Investigating the role of mitochondrial R-loops in heart damage after sepsis
Official title: Mitochondrial R-loop in sepsis-induced cardiomyopathy
Funded at University of Cincinnati · NIH-10991669 · Data updated 2026-11-12
This study is looking at how a certain type of genetic material in our cells might cause heart problems in people who have had sepsis, with the goal of finding new ways to help improve heart health for those who have survived this serious infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | January 12, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $427,202 |
| NIH project number | 5R01HL163148-03 |
| Project ID | NIH-10991669 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced sepsis and are at risk of developing cardiac dysfunction.
✕Less likely to help
Patients who have not experienced sepsis or do not have any cardiac issues may not benefit from this research.
What this research studies
This research focuses on understanding how a specific type of genetic material, known as mitochondrial R-loops, contributes to heart damage in patients who have experienced sepsis. The study aims to uncover the mechanisms by which these R-loops affect inflammation and cardiac function, particularly in heart muscle cells. By examining the relationship between mitochondrial R-loops and immune responses, the research seeks to identify potential new therapeutic targets for improving heart health in sepsis survivors.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect heart function in patients recovering from sepsis.
How similar studies have gone: While the specific focus on mitochondrial R-loops in this context is novel, previous research has shown that targeting mitochondrial dysfunction can improve outcomes in similar conditions.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Huang, Wei — University of Cincinnati
- Study coordinator: Huang, Wei
Related research
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Mitochondrial RNA-DNA hybrids and heart damage after sepsis
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.