Investigating the role of mitochondrial function in heart muscle fibrosis related to pulmonary arterial hypertension.
Official title: Mitochondrial Fission, Calcium, ROS in Right Ventricular Fibrosis
Funded at University of Minnesota · NIH-10879180 · Data updated 2026-11-12
This study is looking at how certain changes in tiny parts of your cells and stress in the heart can lead to problems in the right side of the heart for people with pulmonary arterial hypertension (PAH), with the goal of finding new treatments to help those with heart issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $387,500 |
| NIH project number | 5R01HL160699-02 |
| Project ID | NIH-10879180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pulmonary arterial hypertension who are experiencing right ventricular failure.
✕Less likely to help
Patients with pulmonary arterial hypertension who do not have right ventricular failure or fibrosis may not benefit from this research.
What this research studies
This research focuses on understanding how mitochondrial fission and oxidative stress contribute to fibrosis in the right ventricle of patients with pulmonary arterial hypertension (PAH). By studying the molecular mechanisms involved, particularly the role of specific proteins that regulate mitochondrial function, the research aims to identify potential new therapies for patients suffering from RV failure. The approach includes using preclinical models to observe changes in heart muscle cells and their response to stress, which could lead to innovative treatment options for RV fibrosis.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target and reduce right ventricular fibrosis, improving heart function and survival rates in PAH patients.
How similar studies have gone: Other research has shown promising results in targeting mitochondrial dysfunction in heart diseases, suggesting that this approach could be effective.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Jhun, Bong Sook — University of Minnesota
- Study coordinator: Jhun, Bong Sook
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.