Investigating the role of mitochondrial free radicals in dementia and neuroinflammation
Mitochondrial Complex III Free Radicals in Dementia-Related Proteinopathy and Neuroinflammation
This study is looking at how problems with tiny parts of our cells called mitochondria and harmful substances they produce might lead to diseases like Alzheimer's, and it aims to find new ways to help treat these conditions by testing new compounds that can protect the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10827387 on NIH RePORTER |
What this research studies
This research focuses on understanding how mitochondrial dysfunction and the production of free radicals contribute to neurodegenerative diseases like Alzheimer's. By exploring the mechanisms of oxidative stress and its impact on brain health, the study aims to identify new therapeutic strategies. Researchers will test novel compounds that selectively inhibit harmful free radicals in mitochondria, potentially leading to disease-modifying treatments. The approach includes advanced co-culture techniques to study cellular interactions and responses in a controlled environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or other forms of dementia.
Not a fit: Patients with non-neurodegenerative conditions or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that modify the progression of Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promise in targeting mitochondrial dysfunction for neurodegenerative diseases, suggesting potential for success in this novel approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Orr, Anna Goldshmidt — Weill Medical Coll of Cornell Univ
- Study coordinator: Orr, Anna Goldshmidt
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.