Investigating the role of mitochondrial DNA in lung development issues in premature infants
Official title: MTDNA HAPLOGROUPS IN BPD
Funded at University of Alabama at Birmingham · NIH-11094735 · Data updated 2026-11-12
This study is looking at how certain genetic differences in tiny parts of our cells might affect lung health in very premature babies with a serious lung condition called bronchopulmonary dysplasia, with the hope of finding new ways to help these little ones breathe better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | June 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $518,023 |
| NIH project number | 5R01HL173194-02 |
| Project ID | NIH-11094735 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are extremely preterm infants who are at risk of developing bronchopulmonary dysplasia.
✕Less likely to help
Patients who are not preterm or do not have a diagnosis of bronchopulmonary dysplasia may not benefit from this research.
What this research studies
This research focuses on bronchopulmonary dysplasia (BPD), a serious lung condition affecting extremely preterm infants. It aims to understand how variations in mitochondrial DNA haplogroups influence lung development and the severity of BPD. The study will explore the relationship between mitochondrial dysfunction, oxidative stress, and lung injury, using advanced techniques to analyze mitochondrial function and its impact on lung health. By examining the genetic factors associated with mitochondrial function, the research seeks to identify potential therapeutic targets for improving outcomes in affected infants.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bronchopulmonary dysplasia, enhancing lung health and development in premature infants.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial dysfunction in lung diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Kandasamy, Jegen — University of Alabama at Birmingham
- Study coordinator: Kandasamy, Jegen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.