Investigating the role of mitochondrial and endolysosomal interactions in Alzheimer's disease
Abnormal mitochondrial-endolysosomal contacts in AD
This study is looking at how problems between tiny cell parts called mitochondria and endolysosomes might play a role in Alzheimer's disease, especially for people with a specific gene variant, and it hopes to find new ways to help treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10854885 on NIH RePORTER |
What this research studies
This research focuses on understanding how abnormal interactions between mitochondria and endolysosomes contribute to Alzheimer's disease, particularly in patients carrying the APOE ε4 gene variant. The study examines the effects of these interactions on amyloid beta levels and mitochondrial function, which are critical in the progression of Alzheimer's. By using both human brain samples and mouse models, the research aims to uncover the mechanisms behind these cellular changes and their implications for neurodegeneration. Patients may benefit from insights that could lead to new therapeutic strategies targeting these cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those who are APOE ε4 carriers.
Not a fit: Patients without a diagnosis of Alzheimer's disease or those who do not carry the APOE ε4 variant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of mitochondrial dysfunction in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Wang, Wenzhang — Case Western Reserve University
- Study coordinator: Wang, Wenzhang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.