Investigating the role of mitochondria in malaria parasites
Official title: Essential functions of the mitochondrion in malaria parasites
Funded at Ohio State University · NIH-10951080 · Data updated 2026-11-12
This study is looking at how the tiny powerhouses in malaria parasites work, with the goal of finding new ways to treat severe malaria by targeting these powerhouses, which could help create better medicines that work even when the parasites become resistant to current treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 20, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $459,131 |
| NIH project number | 1DP2AI184824-01 |
| Project ID | NIH-10951080 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living in malaria-endemic regions who may benefit from new treatment options.
✕Less likely to help
Patients who do not have malaria or are not at risk of malaria infection may not receive any benefit from this research.
What this research studies
This research focuses on understanding the essential functions of mitochondria in malaria-causing parasites, particularly Plasmodium falciparum, which is responsible for severe malaria cases. The study aims to develop new antimalarial treatments by targeting the mitochondrion, a critical organelle in the parasite's life cycle. Researchers will employ advanced genetic techniques to identify potential drug targets that are effective across all stages of the parasite's development. By exploring the unique characteristics of the parasite's mitochondria, the research seeks to overcome challenges posed by drug resistance and improve treatment options for malaria.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antimalarial drugs that are more effective against resistant strains of malaria.
How similar studies have gone: Previous research has shown promise in targeting mitochondrial functions in other pathogens, suggesting potential success for this novel approach in malaria treatment.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Rajaram, Krithika — Ohio State University
- Study coordinator: Rajaram, Krithika
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.