Investigating the role of mitochondria in lupus and heart complications
Role of mitochondria in SLE and its cardiovascular complications
This study is looking at how damaged parts of your cells, called mitochondria, might cause inflammation and affect your immune system if you have lupus, and it hopes to find out if certain antibodies in your blood can help predict heart problems in lupus patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10887621 on NIH RePORTER |
What this research studies
This research focuses on understanding how damaged mitochondria contribute to inflammation and immune responses in patients with systemic lupus erythematosus (SLE). The study aims to explore the mechanisms of mitochondrial clearance and the potential clinical utility of autoantibodies targeting mitochondrial proteins in predicting thrombosis development. By analyzing a large cohort of SLE patients over a decade, the researchers will assess the relationship between these autoantibodies and cardiovascular complications. The methodology includes advanced techniques such as flow cytometry and engineered microvessel models to study platelet activation and thrombus formation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus, particularly those experiencing cardiovascular issues.
Not a fit: Patients without a diagnosis of systemic lupus erythematosus or those not experiencing cardiovascular complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting and preventing cardiovascular complications in lupus patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of mitochondrial dysfunction in autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Lood, Jan Christian — University of Washington
- Study coordinator: Lood, Jan Christian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.