Investigating the role of mitochondria and oxidative stress in glaucoma risk and treatment.
Official title: Understanding glaucoma risk and assessment of precision therapies: A study of mitochondria and oxidative stress in human trabecular meshwork
Funded at Washington University · NIH-10930054 · Data updated 2026-11-12
This study is looking at how damage from oxygen affects a part of the eye that helps control pressure and can lead to glaucoma, with the goal of figuring out why some people are more likely to get this condition, so we can create better treatments just for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 30, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $538,692 |
| NIH project number | 5R01EY034529-02 |
| Project ID | NIH-10930054 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for glaucoma, particularly those with a family history or specific genetic profiles.
✕Less likely to help
Patients who do not have glaucoma or are not at risk for developing the condition may not benefit from this research.
What this research studies
This research focuses on understanding how oxidative damage affects the trabecular meshwork in the eye, which is crucial for regulating intraocular pressure and preventing glaucoma. By examining genetic and physiological differences in oxygen metabolism, the study aims to identify why some individuals are at higher risk for developing glaucoma. The researchers will analyze samples from patients undergoing surgery and compare the cellular responses of healthy and glaucomatous trabecular meshwork cells. This approach could lead to more precise therapies tailored to individual patient profiles.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for glaucoma, potentially reducing the risk of blindness.
How similar studies have gone: Previous studies have shown promising results in understanding oxidative stress in glaucoma, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Siegfried, Carla J — Washington University
- Study coordinator: Siegfried, Carla J
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.