Investigating the role of MICU3 in Alzheimer's disease development
Official title: The Role of MICU3 in Alzheimer's Disease Pathogenesis
Funded at Temple Univ of the Commonwealth · NIH-10974464 · Data updated 2026-11-12
This study is looking at how calcium in our cells affects brain health and could play a role in Alzheimer's disease, especially in older adults, with the hope of finding new ways to help improve treatment options for those experiencing memory and thinking problems.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $34,755 |
| NIH project number | 5F30AG082407-02 |
| Project ID | NIH-10974464 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are experiencing symptoms of Alzheimer's disease or are at risk for developing it.
✕Less likely to help
Patients under the age of 65 or those without any signs of cognitive decline may not receive benefit from this research.
What this research studies
This research focuses on understanding how mitochondrial calcium regulation contributes to the development of Alzheimer's disease (AD). It explores the mechanisms behind mitochondrial calcium overload and its effects on brain health, particularly in older adults. By studying specific genetic factors and their impact on calcium transport in neurons, the research aims to uncover new therapeutic targets for AD. Patients may benefit from insights that could lead to innovative treatments for cognitive decline associated with Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve cognitive function and slow the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in targeting mitochondrial dysfunction in Alzheimer's models, suggesting that this approach could yield significant insights.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Cohen, Henry — Temple Univ of the Commonwealth
- Study coordinator: Cohen, Henry
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.