Investigating the role of microtubules in glaucoma
Microtubule Deficit in Glaucoma
['FUNDING_R21'] · TRUSTEES OF INDIANA UNIVERSITY · NIH-11045884
This study is looking at how tiny structures in nerve cells might be affected by high eye pressure in people with glaucoma, using mice to find ways to protect vision and possibly help those with the condition.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TRUSTEES OF INDIANA UNIVERSITY (nih funded) |
| Locations | 1 site (BLOOMINGTON, UNITED STATES) |
| Trial ID | NIH-11045884 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how microtubules, which are essential components of nerve cells, contribute to the development of glaucoma. The study will explore the relationship between elevated eye pressure and the degradation of microtubules in retinal ganglion cells, which are crucial for vision. Using a mouse model of inherited glaucoma, researchers will examine how changes in microtubules may lead to nerve cell damage and loss. The goal is to uncover potential therapeutic targets that could help prevent or reverse damage in glaucoma patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for glaucoma, particularly those with elevated intraocular pressure.
Not a fit: Patients who do not have glaucoma or elevated intraocular pressure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect vision by targeting the underlying mechanisms of glaucoma.
How similar studies have performed: While the specific focus on microtubule deficits in glaucoma is relatively novel, similar research has shown promise in understanding the cellular mechanisms of other neurodegenerative diseases.
Where this research is happening
BLOOMINGTON, UNITED STATES
- TRUSTEES OF INDIANA UNIVERSITY — BLOOMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIM, HYUNGSIK — TRUSTEES OF INDIANA UNIVERSITY
- Study coordinator: LIM, HYUNGSIK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.