Investigating the role of microbes and genes in inflammatory bowel disease in families
The Microbiome, Metabolome, and Genome in Multiplex IBD Family Clusters
This study is looking at how germs and genes might increase the chances of getting inflammatory bowel disease (IBD) in families where several members have it, and it’s for families with three close relatives diagnosed with IBD to help find ways to prevent the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11085241 on NIH RePORTER |
What this research studies
This research focuses on understanding how microbial and genetic factors contribute to the risk of developing inflammatory bowel disease (IBD) in families with multiple affected members. By studying high-risk families with three first-degree relatives diagnosed with IBD, the project aims to identify specific risk factors that could lead to better prevention strategies. The research involves advanced techniques in microbiomics, metabolomics, and genomics to analyze the interplay between these factors. Patients may be involved in providing samples and data to help build a comprehensive understanding of IBD risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of inflammatory bowel disease, particularly those with multiple first-degree relatives affected.
Not a fit: Patients without a family history of inflammatory bowel disease or those who do not have first-degree relatives with the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and personalized treatment options for patients at risk of IBD.
How similar studies have performed: Previous research has shown promise in understanding the microbiome's role in IBD, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Spencer, Elizabeth — Icahn School of Medicine at Mount Sinai
- Study coordinator: Spencer, Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.