Investigating the role of METTL1 in acute myeloid leukemia

Who could benefit from this research

What this research studies

This research focuses on understanding how METTL1, an RNA methyltransferase, contributes to the development and progression of acute myeloid leukemia (AML). By utilizing advanced techniques like CRISPR/Cas9 screening, the study aims to identify the dependence of AML cells on METTL1 and explore its potential as a therapeutic target. The researchers have discovered a promising METTL1 inhibitor that shows significant anti-leukemic activity, which could lead to new treatment options for patients with AML. The goal is to develop small-molecule inhibitors that can effectively target and inhibit METTL1's activity, potentially improving patient outcomes.

Why it matters

Where this research is happening

• Beckman Research Institute/city of Hope
  Duarte, United States Active

Researchers

• Principal investigator: Su, Rui — Beckman Research Institute/city of Hope
• Study coordinator: Su, Rui

Related research

Other NIH-funded projects on the same topics.

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  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11448341

• Targeting FLVCR1-enabled choline use in a aggressive AML subtype

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• Advancing CD70-targeted CAR-NK Therapy for AML

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  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11425793

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.