Investigating the role of metabolism and epigenetics in atherosclerosis
Official title: Metaboloepigenetics and Atherosclerosis
Funded at University of Houston · NIH-11045667 · Data updated 2026-11-12
This study is looking at how changes in metabolism and gene activity might lead to the buildup of plaque in your arteries, which can cause heart problems, and it hopes to find new ways to help treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $550,829 |
| NIH project number | 5R01HL172832-03 |
| Project ID | NIH-11045667 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for atherosclerosis or those with existing cardiovascular conditions.
✕Less likely to help
Patients with non-cardiovascular related health issues or those not at risk for atherosclerosis may not benefit from this research.
What this research studies
This research explores how metabolic processes and epigenetic changes contribute to the development of atherosclerosis, a leading cause of cardiovascular disease. By focusing on the interactions between metabolism and epigenetics, the study aims to uncover new mechanisms that drive the formation of atherosclerotic plaques. The research utilizes advanced techniques to analyze chromatin remodeling and its effects on vascular smooth muscle cells, which are crucial in maintaining healthy blood vessels. Patients may benefit from insights that could lead to more effective treatments targeting the underlying causes of atherosclerosis.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that directly target the mechanisms of atherosclerosis, potentially reducing cardiovascular disease risk.
How similar studies have gone: Previous research has shown promising results in understanding the interplay between metabolism and epigenetics in various diseases, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Houston
Houston, United States Active
Researchers
- Principal investigator: Zhao, Guizhen — University of Houston
- Study coordinator: Zhao, Guizhen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.