Investigating the role of mast cells in Alzheimer's disease
Role of Mast cells in Alzheimer's Disease
This study is looking at how certain immune cells called mast cells might affect the progression of Alzheimer's disease, and it aims to find out if targeting these cells could lead to new treatments for people with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10795106 on NIH RePORTER |
What this research studies
This research explores how mast cells, which are known for their role in allergic responses, may also contribute to the progression of Alzheimer's disease (AD). The study will examine the presence and activity of mast cells in the brains of individuals with AD, focusing on their potential role in inflammation and neurotoxicity. By analyzing blood samples and brain tissue, researchers aim to understand how mast cells might influence disease progression and whether targeting these cells could offer new therapeutic options for patients. The approach includes pharmacological interventions to assess the impact of mast cell inactivation on AD symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with early-stage Alzheimer's disease.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting inflammatory pathways in Alzheimer's disease, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Libby, Peter — Brigham and Women's Hospital
- Study coordinator: Libby, Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.