Investigating the role of Mad1 in promoting breast cancer
Non-canonical roles of Mitotic Arrest Deficient 1 (Mad1) in tumor promotion
This study is looking at how a protein called Mad1 affects breast cancer growth and spread, which could help us find new ways to treat the disease and improve outcomes for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11061331 on NIH RePORTER |
What this research studies
This research focuses on understanding how the protein Mitotic Arrest Deficient 1 (Mad1) contributes to breast cancer progression. It explores Mad1's role not only in cell division but also in destabilizing the p53 tumor suppressor and promoting the secretion of a protein called α5 integrin, which is linked to cancer metastasis. By using advanced techniques like CRISPR/Cas9 and specific inhibitors, the research aims to identify the mechanisms through which Mad1 influences tumor growth and spread. Patients may benefit from insights gained about Mad1's functions, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with breast cancer, particularly those with high levels of Mad1 expression.
Not a fit: Patients with non-breast cancers or those whose tumors do not express Mad1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target Mad1 to inhibit breast cancer progression.
How similar studies have performed: Other research has shown promising results in targeting similar pathways in cancer treatment, suggesting that this approach could be effective.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Weaver, Beth a — University of Wisconsin-Madison
- Study coordinator: Weaver, Beth a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.