Investigating the role of lysosomes in aging and Alzheimer's disease
Lysosomal Metabolomics and pH
This study is looking at how tiny parts of our cells called lysosomes change as we get older and how they might be affected by Alzheimer's disease, using special tools to learn more about their activity in mice, which could help us understand age-related health issues better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11051220 on NIH RePORTER |
What this research studies
This research focuses on understanding how lysosomes, which are essential cellular organelles, change in function and pH as we age and in the context of Alzheimer's disease. By using advanced techniques like mass spectrometry and fluorescence lifetime imaging, the researchers will analyze lysosomal activity and metabolic profiles in mouse models. This work aims to create a detailed atlas of lysosomal changes associated with aging and tauopathies, which could provide insights into the mechanisms of age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults or individuals with early signs of Alzheimer's disease.
Not a fit: Patients with non-age-related neurological disorders or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating Alzheimer's disease and other age-related disorders.
How similar studies have performed: Previous research has shown promising results in understanding lysosomal function in aging and neurodegenerative diseases, indicating that this approach has potential for significant findings.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Li, Feng — Baylor College of Medicine
- Study coordinator: Li, Feng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.