Investigating the role of lymphatics in osteoarthritis among older adults
Official title: Synovial lymphatics and osteoarthritis in aging
Funded at University of Rochester · NIH-10766197 · Data updated 2026-11-12
This study is looking at how the lymphatic system in the joints of older adults might play a role in osteoarthritis, with the hope of finding new ways to improve joint health and reduce pain for those living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 1, 2020 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $384,227 |
| NIH project number | 5R01AG059775-05 |
| Project ID | NIH-10766197 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing symptoms of osteoarthritis.
✕Less likely to help
Patients who are younger or do not have osteoarthritis may not benefit from this research.
What this research studies
This research explores how the lymphatic system in the joints of older adults may contribute to osteoarthritis (OA), a condition affecting millions. The study aims to understand the mechanisms behind impaired lymphatic function in aging joints and how this may lead to cartilage damage and inflammation. By using advanced imaging tools and mouse models, researchers will investigate the relationship between lymphatic signaling and OA progression. The ultimate goal is to identify potential therapeutic strategies that could enhance lymphatic function and alleviate OA symptoms in older patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve joint health and reduce pain for older adults suffering from osteoarthritis.
How similar studies have gone: While the specific approach of targeting lymphatic function in OA is novel, related research has shown promise in understanding joint health and inflammation.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Xing, Lianping — University of Rochester
- Study coordinator: Xing, Lianping
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.