Investigating the role of Ly6h in Alzheimer's disease
Official title: The contribution of Ly6h to Alzheimers Disease
Funded at University of California, San Diego · NIH-10754945 · Data updated 2026-11-12
This study is looking at a protein called Ly6h to see how it affects brain function in people with Alzheimer's disease, hoping to find new ways to help improve memory and thinking skills.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $197,500 |
| NIH project number | 5R21AG080788-02 |
| Project ID | NIH-10754945 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research explores how Ly6h, a protein that inhibits certain receptors in the brain, contributes to the development of Alzheimer's disease. The study will examine the relationship between Ly6h levels and cognitive impairment in Alzheimer's patients, as well as how changes in Ly6h affect brain signaling in animal models. Researchers will use various behavioral tests to assess cognitive function and conduct experiments on neurons to understand the underlying mechanisms. The goal is to uncover new insights that could lead to targeted therapies for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new biomarkers for early detection and novel treatments for Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of cholinergic signaling in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Joiner, William J — University of California, San Diego
- Study coordinator: Joiner, William J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.