Investigating the role of LRRK2 in the progression of Parkinson's disease
LRRK2 in Parkinson's Disease Neurodegeneration
This study is looking at how a specific change in the LRRK2 gene affects the health of brain cells in people with Parkinson's disease, using fruit flies to help find ways to protect these cells and slow down the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10772011 on NIH RePORTER |
What this research studies
This research focuses on understanding how mutations in the LRRK2 gene contribute to the neurodegeneration seen in Parkinson's disease. By studying the effects of the LRRK2 G2019S mutation on neuron growth and maintenance, researchers aim to uncover the mechanisms that lead to dopamine neuron death. The approach involves using genetic models in fruit flies to observe the impact of LRRK2 on neuronal health over time. This could provide insights into potential therapeutic targets for slowing or stopping disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to Parkinson's disease, particularly those with LRRK2 mutations.
Not a fit: Patients without a genetic link to Parkinson's disease or those with advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or delay the progression of Parkinson's disease.
How similar studies have performed: Previous research has shown promise in targeting genetic factors in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Martin, Ian — Oregon Health & Science University
- Study coordinator: Martin, Ian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.