Investigating the role of LRRK2 in Parkinson's disease and inflammation
LRRK2 and inflammasome pathway in Parkinson's disease
This study is looking at how changes in the LRRK2 gene, which is linked to Parkinson's disease, might cause inflammation and damage in the brain, and it's for anyone interested in understanding more about the disease and finding new ways to help treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10884198 on NIH RePORTER |
What this research studies
This research focuses on the LRRK2 gene, which is a significant risk factor for Parkinson's disease (PD). The study aims to understand how mutations in the LRRK2 gene may lead to neuroinflammation and neurodegeneration by interacting with specific proteins involved in the immune response. Researchers will conduct experiments both in laboratory settings and in animal models to explore these interactions and their effects on brain health. The findings could provide insights into the mechanisms of PD and potentially inform new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a genetic predisposition to Parkinson's disease, particularly those with known LRRK2 mutations.
Not a fit: Patients without a genetic link to Parkinson's disease or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for Parkinson's disease by targeting the inflammatory processes involved.
How similar studies have performed: Previous research has shown promising results in understanding the role of LRRK2 in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Smith, Wanli W — Johns Hopkins University
- Study coordinator: Smith, Wanli W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.