Investigating the role of LRRK2 in immune response to SIV in monkeys
Official title: Role of LRRK2 in immunity in a nonhuman primate model of SIV
Funded at Tulane University of Louisiana · NIH-10888237 · Data updated 2026-11-12
This study is looking at how a protein called LRRK2 impacts the immune system's response to a virus similar to HIV, using monkeys to help us understand how it might relate to brain inflammation and diseases like Parkinson's, with the goal of finding new ways to boost the immune response in people dealing with viral infections.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $202,754 |
| NIH project number | 5K01OD036106-02 |
| Project ID | NIH-10888237 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who may experience neurocognitive impairments or are at risk for neurodegenerative diseases.
✕Less likely to help
Patients who do not have HIV or related viral infections may not benefit from this research.
What this research studies
This research explores how the LRRK2 protein affects the immune response to SIV, a virus similar to HIV, using a nonhuman primate model. The study aims to understand the relationship between LRRK2, neuroinflammation, and viral infections, particularly focusing on how SIV infection may influence LRRK2 expression and its implications for neurodegenerative diseases. By examining these interactions, the research seeks to identify potential therapeutic targets that could improve immune responses in individuals affected by viral infections.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance immune responses in patients with HIV and reduce the risk of neurodegenerative diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of immune factors like LRRK2 in viral infections and neuroinflammation, indicating potential for success in this area.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Vail, Krystal — Tulane University of Louisiana
- Study coordinator: Vail, Krystal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.