Investigating the role of LRRK2 and oxidative stress in Parkinson's disease
Official title: LRRK2 and oxidative stress in Parkinson’s disease
Funded at University of Pittsburgh at Pittsburgh · NIH-10795155 · Data updated 2026-11-12
This study is looking at how a protein linked to Parkinson's disease gets activated by stress in cells and how this affects cell function, with the hope of finding new ways to help manage the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | August 23, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $490,660 |
| NIH project number | 1R01NS131137-01A1 |
| Project ID | NIH-10795155 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Parkinson's disease, particularly those with LRRK2 mutations or idiopathic forms of the disease.
✕Less likely to help
Patients with Parkinson's disease caused by factors unrelated to LRRK2 or oxidative stress may not benefit from this research.
What this research studies
This research focuses on understanding how LRRK2, a protein associated with Parkinson's disease, is activated by oxidative stress and its effects on cell function. The study will explore the mechanisms by which LRRK2 activity is stimulated and its relationship with mitochondrial dysfunction, which is known to contribute to Parkinson's disease. By examining the effects of various stressors on LRRK2, the research aims to uncover important insights into the disease's progression and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing Parkinson's disease by targeting LRRK2 activity.
How similar studies have gone: Previous research has shown promising results in understanding the role of oxidative stress in Parkinson's disease, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Greenamyre, J Timothy — University of Pittsburgh at Pittsburgh
- Study coordinator: Greenamyre, J Timothy
Related research
Other NIH-funded projects on the same topics.
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LRRK2 and Oxidative Stress in Parkinson’s Disease
A study from the University of Pittsburgh looks at how a human protein called LRRK2 interacts with oxidative stress to contribute to Parkinson’s disease, with findings aimed at understanding why some people develop the condition and how to target it.
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Understanding LRRK2 and Oxidative Stress in Parkinson's Disease
This project aims to understand how a protein called LRRK2 and cellular stress are connected in Parkinson's disease, especially in people without a known genetic mutation.
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Exploring why certain brain cells are more vulnerable in Parkinson's Disease
This study is looking at why certain brain cells that help with movement are especially vulnerable in Parkinson's Disease, using advanced stem cell models to find out how stress and genetics play a role, with the hope of discovering new ways to treat the condition.
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Investigating why certain brain cells are more vulnerable in Parkinson's Disease
This study is looking at how certain brain cells that are important in Parkinson's Disease can be damaged, using special lab-grown cells to see how stress and genes play a role, with the hope of finding new ways to help treat the condition.
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Gut-brain clues in Parkinson’s disease: supplement to a large registry
A plant-wide supplement to an NIH program will enroll people with Parkinson’s, with and without GI symptoms, plus healthy controls, to study how gut function, brain signals, and sleep rhythms relate to Parkinson’s symptoms.
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Gut-brain connections in Parkinson’s disease: how the gut and environment shape symptoms
A Mayo Clinic team is studying how gut problems, environmental factors, and genetics together influence Parkinson’s disease and its GI symptoms to find biomarkers and better understanding of the disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.