Investigating the role of long non-coding RNAs in ovulation
Official title: Role of Long Non-coding RNAs in the Ovulatory Process
Funded at University of Kentucky · NIH-10988641 · Data updated 2026-11-12
This study is looking at how certain molecules in our cells affect ovulation, which is important for women’s ability to get pregnant, and it hopes to find new ways to help women who have trouble ovulating.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | August 16, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $154,000 |
| NIH project number | 1R03HD113906-01A1 |
| Project ID | NIH-10988641 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of reproductive age who are experiencing difficulties with ovulation or infertility.
✕Less likely to help
Patients who are not experiencing ovulatory issues or those who are not of reproductive age may not benefit from this research.
What this research studies
This research focuses on understanding how long non-coding RNAs (lncRNAs) influence the ovulatory process, which is crucial for women's reproductive health. By utilizing advanced RNA sequencing techniques, the study aims to identify specific lncRNAs that are regulated during the periovulatory period in mouse granulosa cells. The findings could reveal new insights into the mechanisms of ovulation and potential targets for treating conditions like anovulation, which affects many women trying to conceive. This research could ultimately lead to improved fertility treatments and better reproductive health outcomes for women.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for women experiencing infertility due to ovulatory disorders.
How similar studies have gone: While the role of lncRNAs in other biological processes has been studied, this specific investigation into their role in ovulation is relatively novel and untested.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Shrestha, Ketan — University of Kentucky
- Study coordinator: Shrestha, Ketan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.