Investigating the role of local hepcidin in eye health and disease
Local hepcidin in the anterior segment: Physiological and pathological implications
This study is looking at how a hormone called hepcidin works in the front part of the eye and how it might affect conditions like glaucoma by influencing iron levels and stress in eye cells, with the goal of finding new ways to help manage eye diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10546487 on NIH RePORTER |
What this research studies
This research explores how hepcidin, a hormone that regulates iron levels, functions in the anterior segment of the eye, particularly in relation to conditions like glaucoma. It examines how local production of hepcidin in eye cells can influence iron homeostasis and potentially lead to oxidative stress, which is harmful to eye health. The study involves laboratory experiments and models to understand the interactions between hepcidin, cytokines, and oxidative stress in the eye. By identifying these mechanisms, the research aims to uncover new therapeutic targets for managing eye diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with primary open-angle glaucoma or other related ocular conditions.
Not a fit: Patients with conditions unrelated to iron regulation or oxidative stress in the eye may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for glaucoma and other eye conditions by targeting iron regulation and oxidative stress.
How similar studies have performed: Previous research has shown promising results in understanding the role of hepcidin and oxidative stress in other diseases, suggesting potential for success in this area as well.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Singh, Neena — Case Western Reserve University
- Study coordinator: Singh, Neena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.