Investigating the role of lipids in cognitive decline and dementia
Official title: Circulating and Brain Lipidomics, Cognition and Dementia
Funded at Johns Hopkins University · NIH-11193793 · Data updated 2026-11-12
This study is looking at how certain fats in the blood and brain might play a role in Alzheimer's disease and memory loss, and it's for older adults who want to help researchers find new ways to prevent dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 30, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $693,153 |
| NIH project number | 5R01AG085717-02 |
| Project ID | NIH-11193793 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above, particularly those with a family history of dementia or cognitive decline.
✕Less likely to help
Patients under the age of 65 or those without any cognitive impairment or risk factors for dementia may not benefit from this research.
What this research studies
This research focuses on understanding how specific lipids in the blood and brain may contribute to the development of Alzheimer's disease and cognitive decline. By analyzing lipid profiles from both plasma and brain samples, the study aims to identify new mechanisms and potential targets for preventing dementia. Utilizing advanced Lipidyzer technology, researchers will examine lipid species in a large cohort of older adults to uncover associations with cognitive health. This comprehensive approach could lead to significant insights into the biological processes underlying dementia.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying the onset of Alzheimer's disease and cognitive decline in older adults.
How similar studies have gone: Previous research has shown promising results in lipidomics related to cognitive health, indicating that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Arking, Dan E — Johns Hopkins University
- Study coordinator: Arking, Dan E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.