Investigating the role of lipids in cognitive decline and dementia
Circulating and Brain Lipidomics, Cognition and Dementia
This study is looking at how certain fats in the blood and brain might play a role in Alzheimer's disease and memory loss, and it's for older adults who want to help researchers find new ways to prevent dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11193793 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific lipids in the blood and brain may contribute to the development of Alzheimer's disease and cognitive decline. By analyzing lipid profiles from both plasma and brain samples, the study aims to identify new mechanisms and potential targets for preventing dementia. Utilizing advanced Lipidyzer technology, researchers will examine lipid species in a large cohort of older adults to uncover associations with cognitive health. This comprehensive approach could lead to significant insights into the biological processes underlying dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above, particularly those with a family history of dementia or cognitive decline.
Not a fit: Patients under the age of 65 or those without any cognitive impairment or risk factors for dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying the onset of Alzheimer's disease and cognitive decline in older adults.
How similar studies have performed: Previous research has shown promising results in lipidomics related to cognitive health, indicating that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Arking, Dan E — Johns Hopkins University
- Study coordinator: Arking, Dan E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.