Investigating the role of LINE1-ORF0 in lupus
Official title: LINE1-ORF0 in SLE pathogenesis
Funded at Johns Hopkins University · NIH-10778627 · Data updated 2026-11-12
This study is looking at a protein called ORF0 to see how it affects the immune system in people with systemic lupus erythematosus (SLE), which could help find new ways to diagnose and treat the disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 6, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $204,688 |
| NIH project number | 5R21AI176766-02 |
| Project ID | NIH-10778627 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus.
✕Less likely to help
Patients without a diagnosis of systemic lupus erythematosus or those with other unrelated autoimmune conditions may not benefit from this research.
What this research studies
This research focuses on understanding how a specific protein, ORF0, derived from the LINE1 retrotransposon, contributes to the development of systemic lupus erythematosus (SLE), an autoimmune disease. By examining the mechanisms through which ORF0 influences immune responses and the production of autoantibodies, the research aims to uncover new insights into SLE pathogenesis. Patients may benefit from this research as it could lead to the identification of novel biomarkers for diagnosis or targets for therapeutic intervention.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatments for patients with systemic lupus erythematosus.
How similar studies have gone: Previous research has shown promising results in understanding the role of retrotransposons in autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Andrade, Felipe — Johns Hopkins University
- Study coordinator: Andrade, Felipe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.