Investigating the role of LGR5 stem cells in health and disease using a pig model
Official title: A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro
Funded at North Carolina State University Raleigh · NIH-10757048 · Data updated 2026-11-12
This study is exploring special stem cells that help our organs grow and heal, using a unique pig model to learn how these cells work in both healthy and sick situations, especially cancer, so that we can improve treatments for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | January 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $228,000 |
| NIH project number | 5R21OD034080-02 |
| Project ID | NIH-10757048 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with cancers or conditions related to organ development and regeneration.
✕Less likely to help
Patients with non-cancerous conditions unrelated to stem cell function may not receive direct benefits from this research.
What this research studies
This research focuses on understanding LGR5 stem cells, which are crucial for organ development and regeneration, by using a specially developed pig model. The study aims to track and manipulate these cells both in laboratory settings and within living organisms to gain insights into their functions in normal and diseased states, particularly cancer. By overcoming limitations of previous models, this research seeks to provide a more accurate representation of human biology and disease processes. Patients may benefit from advancements in treatment strategies that arise from a better understanding of these stem cells.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for various cancers and regenerative medicine.
How similar studies have gone: Previous research using animal models to study stem cells has shown promising results, indicating potential for success in this novel approach.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Piedrahita, Jorge a — North Carolina State University Raleigh
- Study coordinator: Piedrahita, Jorge a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.