Investigating the role of leukemia stem cells in acute myeloid leukemia
Functional Interrogation of Human Acute Myeloid Leukemia Stem Cells
This study is looking at the tiny cells that help leukemia grow, using special tools to see how changes in their genes affect the disease, with the hope of finding better treatments for people with acute myeloid leukemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11045165 on NIH RePORTER |
What this research studies
This research focuses on understanding the biology of leukemia stem cells (LSCs) in acute myeloid leukemia (AML) using advanced techniques like CRISPR/Cas9 for genome editing. By studying how specific mutations affect the behavior and frequency of these stem cells, the research aims to uncover insights into disease initiation and maintenance. The team will also create induced pluripotent stem cells (iPSCs) from AML samples to explore their potential for developing new treatments. This approach could lead to a better understanding of AML and improved therapeutic strategies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with acute myeloid leukemia, particularly those with specific genetic mutations.
Not a fit: Patients with other types of leukemia or those who are not diagnosed with acute myeloid leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for acute myeloid leukemia by targeting the underlying stem cell mechanisms.
How similar studies have performed: Previous research has shown promise in using similar genetic engineering techniques to study cancer stem cells, indicating potential for success in this area.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Majeti, Ravindra — Stanford University
- Study coordinator: Majeti, Ravindra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.