Investigating the role of leukemia stem cells in acute myeloid leukemia
Human Acute Myeloid Leukemia Stem Cells
This study is looking at a type of blood cancer called acute myeloid leukemia (AML) in older adults to better understand the stubborn cells that help the cancer come back, with the hope of finding new ways to treat it and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10873885 on NIH RePORTER |
What this research studies
This research focuses on understanding acute myeloid leukemia (AML), a serious blood cancer that primarily affects older adults. It examines the unique properties of leukemia stem cells (LSCs), which are responsible for the disease's persistence and resistance to treatment. By studying these cells, researchers aim to uncover why conventional therapies often fail and how LSCs contribute to relapses. The approach includes detailed characterization of LSCs to identify potential new treatment strategies that could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with acute myeloid leukemia, especially those aged 65 and older.
Not a fit: Patients with other types of leukemia or those who are not diagnosed with acute myeloid leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for AML, particularly for older patients who currently have limited options.
How similar studies have performed: Previous research has shown promising results in targeting leukemia stem cells, indicating that this approach could lead to significant advancements in AML treatment.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Majeti, Ravindra — Stanford University
- Study coordinator: Majeti, Ravindra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.