Investigating the role of Larp6 in heart damage caused by alcohol
Larp6 and Alcoholic Cardiomyopathy
This study is looking at how a protein called Larp6 affects heart damage in people with alcoholic cardiomyopathy, and it aims to find new ways to help improve heart health for those dealing with alcohol-related heart issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10841687 on NIH RePORTER |
What this research studies
This research focuses on understanding how Larp6, a protein involved in cardiac fibrosis, contributes to heart damage in individuals with alcoholic cardiomyopathy. The study employs various methods, including genetic manipulation of Larp6 in heart cells and the use of specially designed mouse models to observe the effects of alcohol on heart function. By examining changes in collagen expression and inflammation in the heart, researchers aim to identify potential therapeutic targets for improving heart health in patients affected by alcohol abuse.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcoholic cardiomyopathy or those with a history of significant alcohol consumption.
Not a fit: Patients who do not consume alcohol or have no history of alcohol-related heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce heart damage in patients with alcoholic cardiomyopathy.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cardiac fibrosis, suggesting potential for success in this approach.
Where this research is happening
New Orleans, United States
- Lsu Health Sciences Center — New Orleans, United States (Active)
Researchers
- Principal investigator: Edavettal, Joshua — Lsu Health Sciences Center
- Study coordinator: Edavettal, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.