Investigating the role of KMT2D loss in childhood brain tumors
Heterozygous KMT2D Loss and Medulloblastoma
This study is looking into how medulloblastoma, a common brain tumor in kids, develops and hopes to find new ways to treat it better and with fewer side effects by understanding changes in the cells that help the tumor grow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10885152 on NIH RePORTER |
What this research studies
This research focuses on medulloblastoma, the most common malignant brain tumor in children, and aims to uncover the mechanisms behind its development. It explores how alterations in cellular signaling pathways and epigenetic changes contribute to tumor growth. By studying the role of histone modifications, particularly those involving KMT2D, the research seeks to identify new therapeutic targets that could lead to more effective treatments with fewer side effects. The approach includes advanced techniques like ChIP sequencing to analyze gene regulation in tumor cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with medulloblastoma, particularly those with specific genetic alterations.
Not a fit: Patients with other types of brain tumors or those who do not have the genetic markers being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted treatments for medulloblastoma, reducing long-term side effects for patients.
How similar studies have performed: Previous research has shown promising results in targeting epigenetic modifications in cancer, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Lee, Min Gyu — University of Tx Md Anderson Can Ctr
- Study coordinator: Lee, Min Gyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.