Investigating the role of KLOTHO in protecting against memory loss in Alzheimer's disease
Official title: KLOTHO and Resilience to Synaptic Dysfunction in Preclinical AD
Funded at University of Wisconsin-Madison · NIH-11019750 · Data updated 2026-11-12
This study is looking at how a gene called KLOTHO might help older adults, especially those at risk for Alzheimer's, keep their memory and thinking skills sharp, and it will involve tracking their brain health over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $693,888 |
| NIH project number | 5R01AG077507-03 |
| Project ID | NIH-11019750 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include older adults, particularly those aged 65 and older, who may be at risk for Alzheimer's disease or experiencing early cognitive changes.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any cognitive concerns may not benefit from this research.
What this research studies
This research focuses on understanding how the KLOTHO gene may help protect against synaptic dysfunction associated with Alzheimer's disease (AD). It aims to explore the relationship between KLOTHO levels and cognitive decline in older adults, particularly those at risk for AD. By examining both cross-sectional and longitudinal data, the study seeks to identify factors that contribute to resilience against memory loss and other cognitive impairments. Patients may be involved in assessments that track cognitive function and synaptic health over time.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying cognitive decline in individuals at risk for Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the protective roles of genetic factors like KLOTHO in cognitive health, suggesting potential for success in this area.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Frahmand, Ira — University of Wisconsin-Madison
- Study coordinator: Frahmand, Ira
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.