Investigating the role of Klebsiella quasipneumoniae in urinary tract infections
Official title: Urovirulence and fimbrial regulation in Klebsiella quasipneumoniae
Funded at University of Texas Dallas · NIH-10910160 · Data updated 2026-11-12
This study is looking at how a specific type of bacteria called Klebsiella quasipneumoniae causes urinary tract infections, especially in women, to help find better ways to treat and prevent these infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project start | August 18, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $197,640 |
| NIH project number | 5R21AI169323-02 |
| Project ID | NIH-10910160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adult women who experience recurrent urinary tract infections.
✕Less likely to help
Patients who do not have urinary tract infections or are not female may not benefit from this research.
What this research studies
This research focuses on understanding how Klebsiella quasipneumoniae, a type of bacteria, contributes to urinary tract infections (UTIs) and recurrent UTIs, particularly in women. The study will explore the virulence factors of this bacterium, which are responsible for its ability to adhere to and invade the urinary tract. By using animal models, researchers aim to evaluate the behavior of these bacteria and their resistance to antibiotics, which is a growing concern in treating UTIs. The findings could lead to better understanding and management of UTIs caused by this understudied pathogen.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and preventive strategies for women suffering from recurrent urinary tract infections.
How similar studies have gone: While research on Klebsiella pneumoniae is established, the specific focus on Klebsiella quasipneumoniae is relatively novel and has not been extensively studied.
Where this research is happening
-
University of Texas Dallas
Richardson, United States Active
Researchers
- Principal investigator: De Nisco, Nicole Janell — University of Texas Dallas
- Study coordinator: De Nisco, Nicole Janell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.