Investigating the role of kisspeptins in asthma and airway function
Official title: Kisspeptins in the Airway
Funded at North Dakota State University · NIH-10800816 · Data updated 2026-11-12
This study is looking at how a molecule called kisspeptin might help improve asthma symptoms, especially in women, by understanding how it interacts with hormones and airway inflammation, with the hope of finding better treatments for asthma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Dakota State University NIH-funded |
| Lab location | 1 site (Fargo, United States) |
| Project start | March 5, 2020 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $394,581 |
| NIH project number | 5R01HL146705-05 |
| Project ID | NIH-10800816 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women suffering from asthma, especially those experiencing severe symptoms or inflammation.
✕Less likely to help
Patients with asthma who are male or those whose asthma is not influenced by hormonal factors may not benefit from this research.
What this research studies
This research explores how kisspeptins, a type of signaling molecule, may influence airway smooth muscle behavior in asthma. It focuses on understanding the relationship between sex hormones and airway inflammation, particularly in women who are more affected by asthma. The study aims to determine whether kisspeptins can provide protective effects against airway remodeling and hyperreactivity, which are key features of asthma. By examining human airway smooth muscle cells, the research seeks to uncover new mechanisms that could lead to better treatments for asthma.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve asthma management, particularly for women.
How similar studies have gone: While the specific role of kisspeptins in asthma is novel, related research has shown that hormonal influences can significantly impact airway function and inflammation.
Where this research is happening
-
North Dakota State University
Fargo, United States Active
Researchers
- Principal investigator: Venkatachalem, Sathish — North Dakota State University
- Study coordinator: Venkatachalem, Sathish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.