Investigating the role of junctophilin-2 in fat cell metabolism and obesity
Official title: Junctophilin- 2 in brown Adipocyte Metabolic Regulation and Obesity
Funded at Iowa City VA Medical Center · NIH-10920977 · Data updated 2026-11-12
This study is looking at how a protein called junctophilin-2 (JP2) affects brown fat cells, which help burn energy and manage body weight, to find out how it might help us understand obesity and related health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa City VA Medical Center NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX006139-01A1 |
| Project ID | NIH-10920977 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are struggling with obesity or related metabolic conditions.
✕Less likely to help
Patients who are not affected by obesity or metabolic disorders may not receive any benefit from this research.
What this research studies
This research focuses on understanding how a protein called junctophilin-2 (JP2) affects the metabolism of brown fat cells, which play a crucial role in burning energy and regulating body weight. The study will explore how JP2 influences energy expenditure and the body's response to obesity, particularly in relation to diet and environmental stressors. By examining the mechanisms of JP2 in brown adipose tissue, the research aims to uncover new insights into obesity and related metabolic disorders.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating obesity and its associated health risks, such as type 2 diabetes and cardiovascular disease.
How similar studies have gone: While the specific role of junctophilin-2 in brown adipocytes is still being explored, similar research has shown promising results in understanding the metabolic functions of brown fat and its implications for obesity treatment.
Where this research is happening
-
Iowa City VA Medical Center
Iowa City, United States Active
Researchers
- Principal investigator: Song, Long-Sheng — Iowa City VA Medical Center
- Study coordinator: Song, Long-Sheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.