Investigating the role of Jagged-Notch signaling in liver disease related to obesity
Jagged-Notch signaling in NASH/fibrosis
This study is looking at how a specific signaling process in the liver affects Non-Alcoholic Steatohepatitis (NASH), a serious liver disease often related to obesity, to find new ways to treat it since there are no approved medications yet.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10918305 on NIH RePORTER |
What this research studies
This research focuses on understanding how Jagged-Notch signaling contributes to Non-Alcoholic Steatohepatitis (NASH), a severe liver condition often linked to obesity. By studying liver biopsies from patients and using animal models, the research aims to uncover the mechanisms by which this signaling pathway influences liver inflammation and fibrosis. The goal is to identify potential therapeutic targets that could lead to new treatments for NASH, which currently has no approved medications. Patients with NASH may be monitored for changes in their liver condition as part of this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Non-Alcoholic Steatohepatitis (NASH) or those at risk due to obesity.
Not a fit: Patients with liver diseases unrelated to obesity or those without NASH may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from NASH, potentially reducing the need for liver transplants.
How similar studies have performed: Previous research has shown promising results in targeting the Notch signaling pathway in liver diseases, indicating potential for success in this approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Pajvani, Utpal — Columbia University Health Sciences
- Study coordinator: Pajvani, Utpal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.