Investigating the role of iron in brain changes related to multiple sclerosis
Deep Gray Matter Iron and Disease Progression in Multiple Sclerosis
This study is looking at how iron levels in certain parts of the brain might affect the progression of multiple sclerosis, using special MRI scans to see how these changes could impact the health of important brain cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10877189 on NIH RePORTER |
What this research studies
This research focuses on understanding how iron levels in the deep gray matter of the brain relate to the progression of multiple sclerosis (MS). Using advanced magnetic resonance imaging (MRI), the study aims to non-invasively assess tissue changes in specific brain regions that are crucial for various functions. By examining the relationship between iron availability and the health of oligodendrocytes, the cells responsible for myelination, the research seeks to uncover biological mechanisms that may contribute to neurodegeneration in MS patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis, particularly those experiencing early signs of disease progression.
Not a fit: Patients with other neurological disorders or those without a diagnosis of multiple sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the progression of multiple sclerosis and potential therapeutic targets to slow down or prevent disability.
How similar studies have performed: Previous research has shown promising results in using MRI to study brain changes in multiple sclerosis, indicating that this approach may yield valuable insights.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Schweser, Ferdinand — State University of New York at Buffalo
- Study coordinator: Schweser, Ferdinand
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.