Investigating the role of interleukin-17 in heart failure among older adults
Novel Role of Interleukin-17 in Sympathetic Activation in Heart Failure
This study is looking at how a molecule called interleukin-17 affects heart failure in people aged 65 and older, with the goal of finding new ways to help improve treatment for heart failure by understanding the links between brain inflammation and heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10992616 on NIH RePORTER |
What this research studies
This research focuses on understanding how interleukin-17, a key inflammatory molecule, contributes to heart failure, particularly in individuals aged 65 and older. The study aims to explore the connection between brain inflammation, sympathetic nervous system activation, and cardiac dysfunction. By examining these mechanisms, the researchers hope to identify new therapeutic strategies that could improve treatment outcomes for heart failure patients. The approach involves both laboratory studies and analysis of inflammatory responses in the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing heart failure or related symptoms.
Not a fit: Patients under the age of 65 or those without heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve heart failure management in older adults.
How similar studies have performed: While the role of interleukin-17 in heart failure is a relatively novel area of investigation, previous studies have shown promise in targeting inflammatory pathways for treating various conditions.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Wei, Shunguang — University of Iowa
- Study coordinator: Wei, Shunguang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.