Investigating the role of inflammation in high blood pressure during pregnancy
Hypertension, Inflammation, and Vascular Function
This study is looking at a new way to help pregnant women at risk for preeclampsia by testing a special treatment that could lower high blood pressure and improve health for both moms and their babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project ID | NIH-10828886 on NIH RePORTER |
What this research studies
This research focuses on preeclampsia, a serious condition affecting 5-7% of pregnancies in the U.S., characterized by high blood pressure and immune system activation. The study aims to explore the NLRP3 inflammasome as a potential therapeutic target to improve maternal vascular function and fetal growth. By administering a specific NLRP3 inhibitor, researchers hope to reduce blood pressure and enhance outcomes for mothers and their babies. The approach includes monitoring immune responses and vascular health in pregnant women at risk for preeclampsia.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who are at risk for developing preeclampsia or have been diagnosed with the condition.
Not a fit: Patients who are not pregnant or those without a risk of preeclampsia are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or mitigate the effects of preeclampsia, improving health outcomes for mothers and their infants.
How similar studies have performed: Previous studies have shown promising results with similar approaches targeting the NLRP3 inflammasome, indicating potential for success in this novel application.
Where this research is happening
Jackson, United States
- University of Mississippi Med Ctr — Jackson, United States (Active)
Researchers
- Principal investigator: Cornelius, Denise Creshun — University of Mississippi Med Ctr
- Study coordinator: Cornelius, Denise Creshun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.