Investigating the role of immune cells in HIV reservoirs and viral rebound
Role of myeloid cells in CNS and systemic reservoirs and rebound
This study is looking at how certain immune cells help HIV stick around in the body even when you're on treatment, and by understanding this better, researchers hope to find new ways to help people with HIV live healthier lives and possibly even find a cure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10991360 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain immune cells, specifically myeloid cells, contribute to the persistence of HIV in the body despite treatment. The study aims to analyze viral reservoirs in tissues, which are often overlooked due to the difficulty of obtaining samples. By examining these reservoirs, researchers hope to uncover the characteristics of the virus that lead to its rapid resurgence when treatment is interrupted. This could provide insights into more effective strategies for achieving a cure for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who have not been on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for eliminating HIV reservoirs, potentially paving the way for a cure.
How similar studies have performed: Previous research has shown promise in understanding viral reservoirs, but this specific approach focusing on myeloid cells is relatively novel.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Hope, Thomas — Northwestern University at Chicago
- Study coordinator: Hope, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.