Investigating the role of immune cells in autoimmune kidney disease
NLRP3 Inflammasome Activation, T Follicular Helper Cells and Autoimmunity
This study is looking at how certain immune cells affect the worsening of lupus and its related kidney problems, with the goal of finding new ways to help people with these conditions feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10686392 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain immune cells contribute to the progression of systemic lupus erythematosus (SLE) and its associated kidney disease, proliferative glomerulonephritis (GN). By examining the interactions between different cytokines produced by immune cells in the kidneys, the study aims to uncover the mechanisms that lead to kidney damage and failure. The researchers are utilizing advanced models to identify specific immune cell types and their roles in inflammation, which could lead to new therapeutic strategies for patients suffering from these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus, particularly those experiencing kidney complications.
Not a fit: Patients with autoimmune conditions not related to systemic lupus erythematosus or those without kidney involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for autoimmune kidney diseases, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding immune mechanisms in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Sung, Sun-Sang Joseph — University of Virginia
- Study coordinator: Sung, Sun-Sang Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.