Investigating the role of immune cells in Alzheimer's disease using a 3D model.
Official title: Studying the pathogenic roles of human CD8+ T cells in Alzheimer's disease using a 3D human Peripheral immune Chip.
Funded at Massachusetts General Hospital · NIH-11061844 · Data updated 2026-11-12
This study is looking at how certain immune cells in our body might affect the worsening of Alzheimer's disease, using a special lab model to better understand their interactions with brain cells, which could help find new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $618,299 |
| NIH project number | 5R01AG082328-02 |
| Project ID | NIH-11061844 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at high risk for developing the condition.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding how human CD8+ T cells contribute to the progression of Alzheimer's disease (AD) by utilizing a novel 3D model called the Peripheral immune Chip. The study aims to explore the interactions between these immune cells and brain cells, particularly how they may exacerbate neuroinflammation and neurodegeneration associated with AD. By recreating the disease environment in a laboratory setting, researchers hope to uncover critical mechanisms that drive AD pathology, which could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for Alzheimer's disease, improving outcomes for patients.
How similar studies have gone: Previous research has shown promising results using similar 3D modeling approaches to study neurodegenerative diseases, indicating potential for success in this area.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Kim, Doo Yeon — Massachusetts General Hospital
- Study coordinator: Kim, Doo Yeon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.