Investigating the role of immune cells and antibodies in systemic lupus erythematosus.
Official title: Plasmacytoid dendritic cells and IgA autoantibodies in SLE
Funded at Benaroya Research Inst at Virginia Mason · NIH-11113995 · Data updated 2026-11-12
This study is looking at how certain immune cells react to specific antibodies in people with systemic lupus erythematosus (SLE), especially focusing on women and non-white populations, to help find better ways to diagnose and treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 12, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $853,754 |
| NIH project number | 5R01AI185925-02 |
| Project ID | NIH-11113995 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus, particularly those of Black, Hispanic, or Asian descent.
✕Less likely to help
Patients with other autoimmune diseases or those not diagnosed with systemic lupus erythematosus may not benefit from this research.
What this research studies
This research focuses on systemic lupus erythematosus (SLE), an autoimmune disease that affects various organs and is more common in women and non-white populations. The study aims to understand how specific immune cells, known as plasmacytoid dendritic cells, respond to autoantibodies in SLE, particularly the IgA type. By examining the interactions between these immune cells and nucleic acid-containing immune complexes, the research seeks to uncover mechanisms that contribute to the disease's progression. Patients may benefit from insights that could lead to improved diagnostic and therapeutic strategies for SLE.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with systemic lupus erythematosus.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in autoimmune diseases, but the specific focus on IgA autoantibodies in SLE is relatively novel.
Where this research is happening
-
Benaroya Research Inst at Virginia Mason
Seattle, United States Active
Researchers
- Principal investigator: Hamerman, Jessica a — Benaroya Research Inst at Virginia Mason
- Study coordinator: Hamerman, Jessica a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.