Investigating the role of IL1 in immune issues related to inflammatory bowel disease.
IL1 as a Driver of Mucosal Immune Dysregulation in Inflammatory Bowel Disease
This study is looking at how a protein called interleukin-1 affects the immune system in people with inflammatory bowel disease (like Crohn's disease and ulcerative colitis) to find new ways to help those who aren't getting better with current treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11016987 on NIH RePORTER |
What this research studies
This research focuses on understanding how interleukin-1 (IL1) contributes to immune dysregulation in inflammatory bowel disease (IBD), which includes conditions like Crohn's disease and ulcerative colitis. The study aims to explore the interactions between intestinal microbes and the immune system, particularly how IL1 influences inflammation in the gut. By examining patient samples and animal models, the research seeks to identify new therapeutic targets that could lead to better treatment options for patients who do not respond to current therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, particularly those who have not responded to existing therapies.
Not a fit: Patients with inflammatory bowel disease who are already effectively managed with current therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with inflammatory bowel disease, improving their quality of life and disease management.
How similar studies have performed: Previous research has shown promise in targeting IL1 for treating similar conditions, indicating that this approach could be beneficial.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Mitsialis, Vanessa — Brigham and Women's Hospital
- Study coordinator: Mitsialis, Vanessa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.