Investigating the role of IL-27 in hair loss caused by autoimmune disease
Official title: IL-27 and downstream mechanisms in Alopecia Areata
Funded at University of Iowa · NIH-10907675 · Data updated 2026-11-12
This study is looking at how a substance called IL-27 affects the immune system in people with alopecia areata, a condition that causes hair loss, to find new ways to help treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | September 17, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $329,703 |
| NIH project number | 5R01AR077194-04 |
| Project ID | NIH-10907675 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 20 years of age who are experiencing hair loss due to alopecia areata.
✕Less likely to help
Patients with alopecia areata who are over 20 years old or those with other forms of hair loss unrelated to autoimmune conditions may not benefit from this research.
What this research studies
This research focuses on alopecia areata, an autoimmune condition that leads to hair loss. The study aims to understand how IL-27, a cytokine involved in immune regulation, affects the immune responses that target hair follicles. By exploring the mechanisms of IL-27, researchers hope to identify new anti-inflammatory pathways that could lead to effective treatments for this condition. The research involves analyzing immune responses and cytokine interactions in patients with alopecia areata.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for alopecia areata, improving the quality of life for affected individuals.
How similar studies have gone: Previous research has shown promise in targeting immune responses in autoimmune diseases, suggesting that this approach could be beneficial for alopecia areata as well.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Jabbari, Ali — University of Iowa
- Study coordinator: Jabbari, Ali
Related research
Other NIH-funded projects on the same topics.
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Dupilumab for hair regrowth in children with alopecia areata
This project gives dupilumab to children and teens with widespread alopecia areata, especially those with allergies or high IgE, to help their hair grow back.
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Targeting the NKG2A immune pathway to treat alopecia areata
This project will try blocking the NKG2A immune signal to reduce the immune attack on hair follicles and help people with alopecia areata regrow hair.
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How IL-27 affects hair loss in alopecia areata
Researchers are exploring whether the immune molecule IL-27 helps stop the immune attack that causes hair loss in people with alopecia areata.
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Using hydrogels to treat hair loss in alopecia areata
This study is exploring a new gel treatment for people with alopecia areata, a condition that causes hair loss, to see if it can help stimulate hair regrowth in a safe and effective way.
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Using dupilumab to treat hair loss in children with alopecia areata
This study is looking at how a medication called dupilumab can help kids with alopecia areata, a condition that causes hair loss, by encouraging hair regrowth and making sure the treatment is safe and effective for them.
-
Investigating the NKG2A pathway to treat hair loss in alopecia areata
This study is looking at alopecia areata, a condition that causes hair loss, and is exploring new ways to help by targeting certain immune cells; if you're dealing with this condition, you might have a chance to join trials testing these exciting new treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.