Investigating the role of IL-27 in hair loss caused by autoimmune disease
IL-27 and downstream mechanisms in Alopecia Areata
This study is looking at how a substance called IL-27 affects the immune system in people with alopecia areata, a condition that causes hair loss, to find new ways to help treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10907675 on NIH RePORTER |
What this research studies
This research focuses on alopecia areata, an autoimmune condition that leads to hair loss. The study aims to understand how IL-27, a cytokine involved in immune regulation, affects the immune responses that target hair follicles. By exploring the mechanisms of IL-27, researchers hope to identify new anti-inflammatory pathways that could lead to effective treatments for this condition. The research involves analyzing immune responses and cytokine interactions in patients with alopecia areata.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 20 years of age who are experiencing hair loss due to alopecia areata.
Not a fit: Patients with alopecia areata who are over 20 years old or those with other forms of hair loss unrelated to autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for alopecia areata, improving the quality of life for affected individuals.
How similar studies have performed: Previous research has shown promise in targeting immune responses in autoimmune diseases, suggesting that this approach could be beneficial for alopecia areata as well.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Jabbari, Ali — University of Iowa
- Study coordinator: Jabbari, Ali
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.