Investigating the role of IL-23 in inflammatory arthritis
Official title: The IL-23/IL-17 Axis in Inflammatory Arthritis
Funded at Beth Israel Deaconess Medical Center · NIH-11000864 · Data updated 2026-11-12
This study is looking at how a protein called IL-23 affects inflammatory arthritis, which many people have, to find new ways to treat the condition and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2021 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $586,054 |
| NIH project number | 5R01AR062173-10 |
| Project ID | NIH-11000864 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults suffering from inflammatory arthritis, particularly those who may not respond well to existing treatments.
✕Less likely to help
Patients with non-inflammatory forms of arthritis or those who do not have arthritis may not benefit from this research.
What this research studies
This research focuses on understanding how interleukin-23 (IL-23) contributes to inflammatory arthritis, a condition affecting millions of Americans. The study employs gene-transfer models to explore the mechanisms by which IL-23 induces arthritis, independent of another inflammatory marker, IL-17A. By examining the activation of immune cells, particularly myeloid cells, the research aims to uncover new pathways that could lead to better treatments for arthritis. Patients may benefit from insights gained into the underlying causes of their condition and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the mechanisms of inflammatory arthritis, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in targeting inflammatory pathways in arthritis, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Adamopoulos, Iannis Elias — Beth Israel Deaconess Medical Center
- Study coordinator: Adamopoulos, Iannis Elias
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.