Investigating the role of hydrogen sulfide in airway disease in newborns
Official title: Hydrogen Sulfide in Neonatal Airway Disease
Funded at Mayo Clinic Rochester · NIH-10984979 · Data updated 2026-11-12
This study is looking at how hydrogen sulfide might help protect the lungs of premature babies from damage caused by too much oxygen, with the goal of finding new ways to keep these little ones healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $536,787 |
| NIH project number | 5R01HL160570-03 |
| Project ID | NIH-10984979 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premature infants who are exposed to moderate levels of oxygen and are at risk for airway diseases.
✕Less likely to help
Patients who are not premature or do not have airway diseases may not benefit from this research.
What this research studies
This research explores how hydrogen sulfide (H2S) can protect the developing airways of premature infants from the harmful effects of high oxygen levels. It aims to understand how oxygen exposure leads to airway hyperresponsiveness and remodeling in newborns, and how H2S can counteract these effects. The study will utilize human fetal lung samples and neonatal mouse models to investigate the mechanisms involved. By identifying the protective role of H2S, the research seeks to develop new therapeutic strategies for vulnerable infants.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for airway diseases in premature infants, potentially reducing respiratory complications.
How similar studies have gone: While the specific approach of using hydrogen sulfide in this context is novel, similar studies have shown promise in understanding airway diseases and the effects of oxygen on lung development.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Pabelick, Christina Maria — Mayo Clinic Rochester
- Study coordinator: Pabelick, Christina Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.