Investigating the role of HPV and host factors in a childhood respiratory condition
Official title: HPV and host factors in juvenile onset recurrent respiratory papillomatosis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10993782 · Data updated 2026-11-12
This study is looking at a condition called juvenile-onset recurrent respiratory papillomatosis (JoRRP) in kids, where growths in the throat can cause problems; the researchers want to find out what causes these growths and how to better treat them, using special techniques to study samples from children with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 5, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $446,728 |
| NIH project number | 1R01CA287486-01A1 |
| Project ID | NIH-10993782 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with juvenile-onset recurrent respiratory papillomatosis, particularly those experiencing frequent surgeries due to the condition.
✕Less likely to help
Patients who do not have JoRRP or those with other unrelated respiratory conditions may not benefit from this research.
What this research studies
This research focuses on juvenile-onset recurrent respiratory papillomatosis (JoRRP), a condition in children characterized by recurring growths in the respiratory tract caused by HPV. The study aims to understand the viral and host cell factors that contribute to the development of these papillomas, which can lead to numerous surgeries and potential cancer. By utilizing advanced 3D modeling techniques and analyzing tissue samples from affected children, the researchers hope to identify new therapeutic targets and biomarkers that could improve treatment options and patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies and diagnostic tools that significantly improve the quality of life for children suffering from JoRRP.
How similar studies have gone: Previous research has shown promise in using 3D modeling and transcriptome analysis to understand similar conditions, indicating that this approach may yield valuable insights.
Where this research is happening
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Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Wells, Susanne I — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Wells, Susanne I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.