Investigating the role of HNF4 in blood clotting issues caused by Chagas disease
Official title: Targeting HNF4-induced thrombo-inflammation in Chagas disease
Funded at University of Texas Med Br Galveston · NIH-11143234 · Data updated 2026-11-12
This study is looking at how a protein called HNF4 affects blood clotting in people with Chagas disease, with the goal of finding ways to help improve blood flow and reduce the risk of serious complications like strokes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | June 15, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $179,118 |
| NIH project number | 5R21AI178318-03 |
| Project ID | NIH-11143234 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have been diagnosed with Chagas disease.
✕Less likely to help
Patients who do not have Chagas disease or are under 21 years old may not benefit from this research.
What this research studies
This research focuses on Chagas disease, a serious condition caused by the Trypanosoma cruzi parasite, which leads to significant health issues including blood clotting problems and strokes. The study aims to understand how the HNF4 protein influences the expression of coagulation factors that contribute to these complications. By examining both human data and experimental models, the researchers will explore ways to normalize HNF4 levels to improve blood coagulation dynamics and potentially reduce thromboembolic events in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of strokes and other thromboembolic events in Chagas disease patients.
How similar studies have gone: Previous research has shown promising results in targeting coagulation factors in other diseases, suggesting potential success for this novel approach in Chagas disease.
Where this research is happening
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University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Garg, Nisha Jain — University of Texas Med Br Galveston
- Study coordinator: Garg, Nisha Jain
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.