Investigating the role of HMGA1 in pancreatic cancer development
Official title: Targeting HMGA1 Tumor-Stromal Networks in Pancreatic Carcinogenesis
Funded at Johns Hopkins University · NIH-10972820 · Data updated 2026-11-12
This study is looking at how a gene called HMGA1 affects the growth of a tough type of pancreatic cancer, with the goal of finding new ways to treat patients who have it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $431,561 |
| NIH project number | 1R01CA293602-01 |
| Project ID | NIH-10972820 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma or those at high risk for developing this type of cancer.
✕Less likely to help
Patients with other types of cancer or those without pancreatic cancer may not benefit from this research.
What this research studies
This research focuses on understanding how the HMGA1 gene influences the development of pancreatic ductal adenocarcinomas (PDAC), a particularly aggressive form of cancer. The study aims to explore the mechanisms by which HMGA1 contributes to tumor growth and the surrounding stroma, which is the supportive tissue in tumors. By examining the effects of silencing HMGA1 in laboratory models, the researchers hope to identify new therapeutic targets that could lead to better treatment options for patients with PDAC.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that improve survival rates for patients with pancreatic cancer.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways in other cancers, suggesting that this approach may be effective in pancreatic cancer as well.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Resar, Linda M S — Johns Hopkins University
- Study coordinator: Resar, Linda M S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.